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The influence of induction technique on intubating conditions 1 min after rocuronium administration: a comparison of a propofol‐ephedrine combination and propofol
Author(s) -
Tan C. H.,
Onisong M. K.,
Chiu W. K. Y.
Publication year - 2002
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.0003-2409.2001.02449.x
Subject(s) - propofol , rocuronium , medicine , ephedrine , anesthesia , intubation , rocuronium bromide , tracheal intubation
Summary We conducted a double blind, prospective, controlled trial comparing intubating conditions after induction with a propofol‐ephedrine combination or propofol alone, followed by rocuronium. One hundred adult patients were randomly assigned to receive either propofol 2.5 mg.kg −1 and ephedrine 15 mg in combination or propofol 2.5 mg.kg −1 given over 30 s, followed by rocuronium 0.6 mg.kg −1 given over 5 s. Tracheal intubation was performed 1 min later. Jaw relaxation, vocal cord position and diaphragmatic response were used to assess intubation conditions. Tracheal intubation was successful and acceptable in all patients. There was a significantly higher proportion of intubating conditions graded as ‘excellent’ in the propofol‐ephedrine group (84%) than in the propofol group (32%) (p < 0.0001). Vocal cord position and response to intubation were significantly better in the propofol‐ephedrine group, although jaw relaxation was similar. Mean arterial pressure was maintained at pre‐induction levels in the propofol‐ephedrine group. In conclusion, induction with propofol and ephedrine in combination provided significantly better intubating conditions than propofol alone, when followed by rocuronium.