Is Allopurinol Beneficial in the Prevention of Renal Ischaemia—Reperfusion Injury in the Rat?: Evaluation by Near-Infrared Spectroscopy | Zendy

DL Vaughan | Zendy; Y. A. B. D. Wickramasinghe | Zendy; Ginny Russell | Zendy; MAUREEN S. THORNILEY | Zendy; R. Houston | Zendy; Ernie Ruban | Zendy; P. Rolfe | Zendy

Open Access

Is Allopurinol Beneficial in the Prevention of Renal Ischaemia—Reperfusion Injury in the Rat?: Evaluation by Near-Infrared Spectroscopy

Author(s) -

DL Vaughan,

Y. A. B. D. Wickramasinghe,

Ginny Russell,

MAUREEN S. THORNILEY,

R. Houston,

Ernie Ruban,

P. Rolfe

Publication year - 1995

Publication title -

clinical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.91

H-Index - 138

eISSN - 1470-8736

pISSN - 0143-5221

DOI - 10.1042/cs0880359

Subject(s) - allopurinol , ischemia , medicine , reperfusion injury , kidney , pharmacology , oxygenation , anesthesia

1. The role of allopurinol in the protection of kidney function following ischaemia-reperfusion injury has been investigated using the novel technique of near-infrared spectroscopy. 2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. 3. Allopurinol infusion increased the rate of reperfusion of oxygenated blood seen in control rats (P < 0.05). 4. Allopurinol enhanced the rate of tissue oxygenation during early reperfusion (P < 0.01). 5. This study provides further evidence for the proposed benefits of allopurinol in ischaemia-reperfusion injury. Furthermore, the potential of near-infrared spectroscopy as a technique of value in interventional studies of this nature is confirmed.

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