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Long‐term hydrogen peroxide exposure potentiates anoikis resistance and anchorage‐independent growth in lung carcinoma cells
Author(s) -
Halim Hasseri,
Chanvorachote Pithi
Publication year - 2012
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20120111
Subject(s) - anoikis , downregulation and upregulation , hydrogen peroxide , cancer research , lung cancer , chemistry , cancer cell , cancer , biology , medicine , biochemistry , gene
Hydrogen peroxide (H 2 O 2 ) is upregulated in tumour microenvironments and may contribute to effects on metastatic cancer cells. This study demonstrates that treatment of lung carcinoma and melanoma cells with H 2 O 2 for 14 days results in an induction of anoikis resistance and growth in an anchorage‐independent condition. H 2 O 2 exposure increased the Cav‐1 (caveolin‐1) level through an increase of Cav‐1 mRNA with minimal effect on protein degradation. Upregulation of Cav‐1 induced anoikis resistance and facilitated growth in a detached manner. The findings show a novel role of hydrogen peroxide in the regulation of metastatic potential of cancer cells.