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Mechanotransduction in cells 1
Author(s) -
Goldmann Wolfgang H
Publication year - 2012
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20120071
Subject(s) - mechanotransduction , focal adhesion , microbiology and biotechnology , cytoskeleton , extracellular matrix , integrin , cell , myosin , cell adhesion , transmembrane protein , chemistry , contractility , cell metabolism , biology , signal transduction , receptor , biochemistry , endocrinology
Cell—matrix and cell—cell adhesions critically influence cell metabolism, protein synthesis, cell survival, cytoskeletal architecture and consequently cell mechanical properties such as migration, spreading and contraction. An important group of adhesive transmembrane receptors that mechanically link the ECM (extracellular matrix) with the internal cytoskeleton are integrins which are intimately connected with the FAs (focal adhesions) which consists of many proteins. The transient formation of FAs is greatly augmented either through externally applied tension to the cell or internally through myosin II‐driven cell contractility. Exactly which protein(s) within FAs sense, transmit and respond to mechanical stress is currently debated and numerous candidates have been proposed.