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Quantity and proliferation rate of mesenchymal stem cells in human cord blood during gestation
Author(s) -
Ma LanLan,
Meng FanBiao,
Shi Ping,
Li Gang,
Pang XiNing
Publication year - 2012
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20110173
Subject(s) - mesenchymal stem cell , umbilical cord , andrology , cd44 , cord blood , gestation , cd34 , population , stem cell , cord lining , immunology , medicine , cell , biology , embryonic stem cell , pregnancy , microbiology and biotechnology , pathology , adult stem cell , biochemistry , genetics , environmental health , gene
UCB (umbilical cord blood) as a resource of MSCs (mesenchymal stem cells) is widely accepted, but the quantity and characteristics of UCB‐MSCs from different gestational ages have not been well studied. We have quantified the number of MSCs in UCB at different gestational ages using a multi‐colour flowcytometer and compared the cell proliferation rates of these UCB‐MSCs. Defining MSCs as CD44+/CD105+/CD34 −/CD45 population, their numbers declined in the UCB at the gestational age. Proliferation rates were significantly higher in UCB before term than at full term. Non‐full term UCB samples may be a better source of MSCs.