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Involvement of interleukin‐1β mediated nuclear factor κB signalling pathways to down‐regulate prostate‐specific antigen and cell proliferation in LNCaP prostate cancer cells
Author(s) -
Bouraoui Yosra,
Rais Nawfel Ben,
Culig Zoran,
Oueslati Ridha
Publication year - 2012
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20100922
Subject(s) - lncap , protein kinase b , cancer research , prostate cancer , cell growth , nf κb , signal transduction , pi3k/akt/mtor pathway , biology , medicine , microbiology and biotechnology , cancer , biochemistry
Involvement of NF‐κB (nuclear factor κB) mediated by IL‐1β (interleukin‐1β) on cell proliferation and PSA (prostate‐specific antigen) production of LNCaP prostate cell lines and the possible cross‐talk with Akt (also known as protein kinase B) signalling pathway has been investigated. NF‐κB and Akt were analysed by Western blotting from LNCaP cells treated by IL‐1β before proliferation and PSA production were measured. IL‐1β inhibited proliferation and decreased PSA production. The Akt pathway was not sensitive, whereas NF‐κB phosphorylation occurred as a result of treatment. PSA production and proliferation of LNCaP cells were down‐regulated by NF‐κB mediated by IL‐1β promoting anti‐apoptotic signalling and co‐suppressor factors of PSA expression. IL‐1β through NF‐κB activation provides a rationale for therapeutic approaches in the anticancer treatment of prostate.