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Islet organogenesis, angiogenesis and innervation
Author(s) -
Cerf Marlon E.
Publication year - 2011
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20100780
Subject(s) - islet , organogenesis , angiogenesis , glucose homeostasis , biology , pancreas , homeostasis , endocrine system , microbiology and biotechnology , endocrinology , enteroendocrine cell , medicine , pancreatic islets , diabetes mellitus , biochemistry , insulin resistance , cancer research , gene , hormone
The pancreas is characterized by a major component, an exocrine and ductal system involved in digestion, and a minor component, the endocrine islets represented by islet micro‐organs that tightly regulate glucose homoeostasis. Pancreatic organogenesis is strictly co‐ordinated by transcription factors that are expressed sequentially to yield functional islets capable of maintaining glucose homoeostasis. Angiogenesis and innervation complete islet development, equipping islets to respond to metabolic demands. Proper regulation of this triad of processes during development is critical for establishing functional islets.