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On the possible use of exogenous histones in cell technology
Author(s) -
Goryukhina Olga A.,
Martyushin Sergey V.,
Pinaev George P.
Publication year - 2011
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20100741
Subject(s) - histone , in vitro , penetration (warfare) , microbiology and biotechnology , cell , membrane , cell adhesion , microsphere , nanotechnology , biophysics , chemistry , adhesion , biology , materials science , biochemistry , chemical engineering , engineering , dna , organic chemistry , operations research
The prospect of developing transport systems using histones for site‐specific delivery of therapeutic agents that have poor penetration characteristics through cellular membranes and tissue barriers has been investigated. Histones immobilized on microspheres can also be used to modify surfaces intended for cell cultivation, facilitating adhesion, proliferation and network formation by interactions of cells through contacts with several microspheres. They can be applied to three‐dimensional pore matrices that are designed for producing tissue‐like structures in vitro .