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Polymethyl‐methacrylate—sorbitol‐based capsules as local drug delivery vehicles: a preliminary study
Author(s) -
Frank Dorottya,
Cseh Gellért,
Nagy Tamás,
Pótó László,
Kocsis Béla,
Miseta Attila
Publication year - 2011
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20100712
Subject(s) - sorbitol , materials science , drug delivery , polymethyl methacrylate , chemical engineering , chemistry , composite material , polymer , nanotechnology , organic chemistry , engineering
Local delivery of antibiotics via PMMA (polymethyl‐methacrylate) has been widely used in the treatment of chronic osteomyelitis for over 40 years. Unfortunately, PMMA is water insoluble, which seriously limits antibiotic delivery. In addition, the polymerization temperature of PMMA is high, and consequently, only heat‐stable antibiotics can be used. Therefore our aim has been to develop an effective antibiotic delivery system, which can be loaded with a wide variety of drugs and deliver the molecules in a predictable manner. Capsules with wall thicknesses of 0.3–0.6 mm from PMMA mixtures containing 40–70 w/w% (weight percent) of sorbitol were prepared and their permeability tested with BPB (Bromophenol Blue). Sorbitol content and wall thickness correlated with the BPB release. SEM (scanning electron microscopy) showed that the canalization of capsules also was well correlated with both sorbitol content and wall thickness. The PMMA—sorbitol‐based capsule can potentially be a versatile tool in assuring effective delivery of antibiotics and other substances.