CCZ1 ,  MON1  and  YPT7  genes are involved in pexophagy, the Cvt pathway and non‐specific macroautophagy in the methylotrophic yeast  Pichia pastoris | Zendy

Polupanov Andriy S. | Zendy; Nazarko Volodymyr Y. | Zendy; Sibirny Andriy A. | Zendy

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CCZ1 , MON1 and YPT7 genes are involved in pexophagy, the Cvt pathway and non‐specific macroautophagy in the methylotrophic yeast Pichia pastoris

Author(s) -

Polupanov Andriy S.,

Nazarko Volodymyr Y.,

Sibirny Andriy A.

Publication year - 2011

Publication title -

cell biology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.932

H-Index - 77

eISSN - 1095-8355

pISSN - 1065-6995

DOI - 10.1042/cbi20100547

Subject(s) - pichia pastoris , gene , peroxisome , yeast , biology , vacuole , saccharomyces cerevisiae , biochemistry , cytoplasm , recombinant dna

Orthologues of Saccharomyces cerevisiae CCZ1 , MON1 and YPT7 genes in the methylotrophic yeast, Pichia pastoris , have been identified. These genes encode proteins, which act as a complex, being involved in degradation of oleate‐induced peroxisomes, Cvt (cytoplasm to vacuole targeting) pathway and non‐specific macroautophagy in S. cerevisiae . CCZ1 , MON1 and YPT7 gene orthologues are essential for multiple delivery pathways in P. pastoris . Strains with deletion of either of these genes displayed complete deficiency in pexophagy, non‐specific macroautophagy and the biosynthetic Cvt pathway. The data suggest that CCZ1 , MON1 and YPT7 genes are involved in degradation of both small oleate‐induced and large methanol‐induced peroxisomes. The data suggest conservative functions of CCZ1 , MON1 and YPT7 genes among yeast species.

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