Premium
Stem cell‐conditioned medium does not protect against kidney failure
Author(s) -
Gheisari Yousof,
Ahmadbeigi Naser,
Naderi Mahmood,
Nassiri Seyed Mahdi,
Nadri Samad,
Soleimani Masoud
Publication year - 2011
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20100183
Subject(s) - renal stem cell , mesenchymal stem cell , stem cell , paracrine signalling , umbilical cord , medicine , kidney , adult stem cell , bone marrow , pharmacology , cancer research , immunology , biology , microbiology and biotechnology , pathology , endothelial stem cell , in vitro , biochemistry , progenitor cell , receptor
Paracrine secretion of mediators may be the main route by which stem cells protect against injuries. Stem cells commonly secrete different bioactive molecules. In this study, we examined the hypothesis that administration of conditioned media of stem cells can diminish the burden of kidney injury. A mouse model of cisplatin‐induced nephropathy was developed to test the putative renoprotective effects of conditioned media of human umbilical cord blood USSCs (unrestricted somatic stem cells) as well as mouse bone marrow MSCs (mesenchymal stem cells). None of these two types of conditioned medium could protect against kidney failure in terms of serum urea and creatinine, histopathologic examinations and physical activity score. Neither MSC‐ nor USSC‐conditioned media were effective in protecting against kidney injury in our study. Possible explanations for our observations are offered, and related literature is reviewed.