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Adenosine induces G 2 /M cell‐cycle arrest by inhibiting cell mitosis progression
Author(s) -
Jia KunZhi,
Tang Bo,
Yu Lu,
Cheng Wei,
Zhang Rong,
Zhang JianFa,
Hua ZiChun
Publication year - 2010
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1042/cbi20090136
Subject(s) - microbiology and biotechnology , adenosine , mitosis , cell cycle , cell cycle checkpoint , anaphase , cyclin b , cell , chemistry , biology , cyclin , biochemistry
Cellular adenosine accumulates under stress conditions. Few papers on adenosine are concerned with its function in the cell cycle. The cell cycle is the essential mechanism by which all living things reproduce and the target machinery when cells encounter stresses, so it is necessary to examine the relationship between adenosine and the cell cycle. In the present study, adenosine was found to induce G 2 /M cell‐cycle arrest. Furthermore, adenosine was found to modulate the expression of some important proteins in the cell cycle, such as cyclin B and p21, and to inhibit the transition of metaphase to anaphase in mitosis.