Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation | Zendy

Shuai Shi | Zendy; Xinyu Ji | Zendy; Jingjing Shi | Zendy; Shuqing Shi | Zendy; Fei She | Zendy; Qiuyan Zhang | Zendy; Yu Dong | Zendy; Hanming Cui | Zendy; Yuanhui Hu | Zendy

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Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation

Author(s) -

Shuai Shi,

Xinyu Ji,

Jingjing Shi,

Shuqing Shi,

Fei She,

Qiuyan Zhang,

Yu Dong,

Hanming Cui,

Yuanhui Hu

Publication year - 2022

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20212812

Subject(s) - kegg , andrographolide , pubchem , andrographis paniculata , drugbank , computational biology , toxicogenomics , mechanism (biology) , gene , biology , pharmacology , bioinformatics , biochemistry , transcriptome , medicine , gene expression , drug , philosophy , epistemology , pathology , alternative medicine

Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular protective effects. The present study aimed to explore the effects of AG on the progression of atherosclerosis and to investigate related mechanisms via network pharmacology.

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