The circadian rhythm and core gene Period2 regulate the chemotherapy effect and multidrug resistance of ovarian cancer through the PI3K signaling pathway | Zendy

Zhaoxia Wang | Zendy; Honghong Wang | Zendy; Hongrui Guo | Zendy; FengYan Li | Zendy; Weiwei Wu | Zendy; Sanyuan Zhang | Zendy; Tong Wang | Zendy

Open Access

The circadian rhythm and core gene Period2 regulate the chemotherapy effect and multidrug resistance of ovarian cancer through the PI3K signaling pathway

Author(s) -

Zhaoxia Wang,

Honghong Wang,

Hongrui Guo,

FengYan Li,

Weiwei Wu,

Sanyuan Zhang,

Tong Wang

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20202683

Subject(s) - ovarian cancer , per2 , per1 , cancer research , biology , medicine , cancer , protein kinase b , endocrinology , pi3k/akt/mtor pathway , circadian rhythm , circadian clock , clock , signal transduction , oncology , microbiology and biotechnology

Ovarian cancer is the most lethal cancer in the female reproductive system. It has been shown that 'time chemotherapy' of ovarian cancer has an important impact on the chemotherapy effect and prognosis of patients, but the specific mechanism is not known.

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