Open AccessThe circadian rhythm and core gene Period2 regulate the chemotherapy effect and multidrug resistance of ovarian cancer through the PI3K signaling pathway
Author(s) -
Zhaoxia Wang,
Honghong Wang,
Hongrui Guo,
Fengyan Li,
Weiwei Wu,
Sanyuan Zhang,
Tong Wang
Publication year - 2020
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20202683
Subject(s) - ovarian cancer , per2 , per1 , cancer research , biology , medicine , cancer , protein kinase b , endocrinology , circadian clock , pi3k/akt/mtor pathway , circadian rhythm , clock , oncology , signal transduction , microbiology and biotechnology
Ovarian cancer is the most lethal cancer in the female reproductive system. It has been shown that 'time chemotherapy' of ovarian cancer has an important impact on the chemotherapy effect and prognosis of patients, but the specific mechanism is not known.