Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs | Zendy

Nana Wen | Zendy; Lu Xue | Zendy; Yongle Yang | Zendy; Shunbo Shi | Zendy; Qinghua Liu | Zendy; Congli Cai | Zendy; Jinhua Shen | Zendy

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Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs

Author(s) -

Nana Wen,

Lu Xue,

Yongle Yang,

Shunbo Shi,

Qinghua Liu,

Congli Cai,

Jinhua Shen

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20190534

Subject(s) - alkaloid , coptisine , blockade , chemistry , anatomy , pharmacology , biology , stereochemistry , biochemistry , receptor , palmatine

Recently, effective and purified ingredients of traditional Chinese medicine (TCM) were extracted to play crucial roles in the treatment of pulmonary diseases. Our previous research focused on TCM drug screening aimed at abnormal airway muscle contraction during respiratory diseases. Coptisine, an effective ingredient extracted from bitter herbs has shown a series of antioxidant, antibacterial, cardioprotective and neuroprotective pharmacological properties. In the current study, we questioned whether coptisine could also participate in asthma treatment through relaxing abnormal contracted mouse airway smooth muscle (ASM). The present study aimed to characterize the relaxant effects of coptisine on mouse ASM and uncover the underlying molecular mechanisms.

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