Open AccessInvestigation of dacomitinib on reducing cell necrosis and enhancing cell apoptosis in C6 glioma rat model by MRI
Author(s) -
Wangsheng Chen,
Liu Hong,
Fei Wang,
Jianjun Li
Publication year - 2019
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20190006
Subject(s) - glioma , apoptosis , necrosis , h&e stain , pharmacology , immunohistochemistry , medicine , pathology , cancer research , chemistry , biochemistry
Glioma is one of the most epidemic and obstinate types of cancer in the central nervous system (CNS) with poor survival rate. Dacomitinib inhibited cell viability and proliferation of epidermal growth factor receptor ( EGFR )-amplified glioma. In the present study, the regional effects of Dacomitinib on tumor necrosis was investigated.