Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling | Zendy

Lixiang Sun | Zendy; Xiuyong Hu | Zendy; WanMing Chen | Zendy; Wei He | Zendy; Zhiming Zhang | Zendy; Tuanlao Wang | Zendy

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Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling

Author(s) -

Lixiang Sun,

Xiuyong Hu,

WanMing Chen,

Wei He,

Zhiming Zhang,

Tuanlao Wang

Publication year - 2016

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20150205

Subject(s) - sorting nexin , pdz domain , frizzled , microbiology and biotechnology , retromer , endocytosis , chemistry , endosome , gtpase activating protein , wnt signaling pathway , biology , signal transduction , receptor , biochemistry , g protein , intracellular

This work found that sorting nexin 27 (SNX27) interacts with Frizzled receptors (Fzds) through PDZ domain interaction, which act as novel interacting partners for SNX27. Functional investigation of the interaction of SNX27 with Fzd7 revealed that SNX27 promotes the degradation of Fzd7, thus down-regulating Wnt signalling.

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