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This work found that sorting nexin 27 (SNX27) interacts with Frizzled receptors (Fzds) through PDZ domain interaction, which act as novel interacting partners for SNX27. Functional investigation of the interaction of SNX27 with Fzd7 revealed that SNX27 promotes the degradation of Fzd7, thus down-regulating Wnt signalling.

Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling