Open AccessSearching for methyllysine-binding aromatic cages
Author(s) -
Kendra R. Vann,
Yashavantha Vishweshwaraiah,
Nikolay V. Dokholyan,
Tatiana G. Kutateladze
Publication year - 2021
Publication title -
biochemical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.706
H-Index - 265
eISSN - 1470-8728
pISSN - 0264-6021
DOI - 10.1042/bcj20210106
Subject(s) - methylation , histone , biology , cytoplasm , protein data bank (rcsb pdb) , biochemistry , lysine , computational biology , amino acid , dna
Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated with methylation of non-histone proteins, particularly in the cytoplasm of the cell, are not well understood. Here, we describe a search for potential methyllysine readers using a rapid structural motif-mining algorithm Erebus, the PDB database, and knowledge of the methyllysine binding mechanisms.