Open AccessRAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics
Author(s) -
Walaa E Kattan,
John F. Hancock
Publication year - 2020
Publication title -
biochemical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.706
H-Index - 265
eISSN - 1470-8728
pISSN - 0264-6021
DOI - 10.1042/bcj20190839
Subject(s) - kras , gene isoform , function (biology) , biology , microbiology and biotechnology , computational biology , membrane protein , cell growth , membrane biology , biochemistry , chemistry , mutation , membrane , gene
The three human RAS proteins are mutated and constitutively activated in ∼20% of cancers leading to cell growth and proliferation. For the past three decades, many attempts have been made to inhibit these proteins with little success. Recently; however, multiple methods have emerged to inhibit KRAS, the most prevalently mutated isoform. These methods and the underlying biology will be discussed in this review with a special focus on KRAS-plasma membrane interactions.