RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics | Zendy

Walaa E. Kattan | Zendy; John F. Hancock | Zendy

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RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics

Author(s) -

Walaa E. Kattan,

John F. Hancock

Publication year - 2020

Publication title -

biochemical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.706

H-Index - 265

eISSN - 1470-8728

pISSN - 0264-6021

DOI - 10.1042/bcj20190839

Subject(s) - kras , gene isoform , function (biology) , biology , microbiology and biotechnology , computational biology , membrane protein , cell growth , membrane biology , biochemistry , chemistry , mutation , membrane , gene

The three human RAS proteins are mutated and constitutively activated in ∼20% of cancers leading to cell growth and proliferation. For the past three decades, many attempts have been made to inhibit these proteins with little success. Recently; however, multiple methods have emerged to inhibit KRAS, the most prevalently mutated isoform. These methods and the underlying biology will be discussed in this review with a special focus on KRAS-plasma membrane interactions.

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