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Non‐coding RNAs and their epigenetic regulatory mechanisms
Author(s) -
Zhou Huihui,
Hu Hu,
Lai Maode
Publication year - 2010
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1042/bc20100029
Subject(s) - epigenetics , biology , non coding rna , microrna , computational biology , regulation of gene expression , gene , genetics , epigenesis , gene expression , bioinformatics , dna methylation
It is widely accepted that ncRNAs (non‐coding RNAs), as opposed to protein‐coding RNAs, represent the majority of human transcripts; and the regulatory roles of many of these ncRNAs have been elucidated over the past decade. One important role so far recognized for ncRNAs is their participation in the epigenetic regulation of genes. Indeed, it is becoming increasingly apparent that most epigenetic mechanisms of gene expression are controlled by ncRNAs. In this review, the different types of ncRNA that are strongly linked to epigenetic regulation are characterized and their possible mechanisms discussed.