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Cytoplasmic signalling by the c‐Abl tyrosine kinase in normal and cancer cells
Author(s) -
Sirvent Audrey,
Benistant Christine,
Roche Serge
Publication year - 2008
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1042/bc20080020
Subject(s) - biology , cytoplasm , microbiology and biotechnology , receptor tyrosine kinase , tyrosine kinase , endocytosis , abl , signal transduction , receptor , proto oncogene tyrosine protein kinase src , ror1 , platelet derived growth factor receptor , growth factor , biochemistry
c‐Abl is a non‐receptor tyrosine kinase which is localized both in the nucleus and cytoplasm, and is involved in the regulation of cell growth, survival and morphogenesis. Although c‐Abl nuclear function has been extensively studied, recent data also indicate an important role in cytoplasmic signalling through mitogenic and adhesive receptors. Here, we review the mechanisms by which growth factors promote cytoplasmic c‐Abl activation and signalling and its function in the induction of DNA synthesis, changes in cell morphology and receptor endocytosis. The importance of de‐regulated c‐Abl cytoplasmic signalling in solid tumours is also discussed.