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What is the function of neuronal AP‐3?
Author(s) -
Danglot Lydia,
Galli Thierry
Publication year - 2007
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1042/bc20070029
Subject(s) - biology , synaptic vesicle recycling , synaptic vesicle , exocytosis , vesicle fusion , endocytosis , kiss and run fusion , microbiology and biotechnology , snap25 , munc 18 , signal transducing adaptor protein , vesicle , neurotransmission , dynamin , endocytic cycle , biochemistry , receptor , secretion , signal transduction , membrane
Neurotransmission requires the proper organization and rapid recycling of synaptic vesicles. Rapid retrieval has been suggested to occur either by kiss‐and‐stay or kiss‐and‐run mechanisms, whereas classical recycling is mediated by clathrin‐dependent endocytosis. Molecular coats are key components in the selection of cargos, AP‐2 (adaptor protein 2) playing a prominent role in synaptic vesicle endocytosis. Another coat protein, AP‐3, has been implicated in synaptic vesicle biogenesis and in the generation of secretory and lysosomal‐related organelles. In the present review, we will particularly focus on the recent data concerning the recycling of synaptic vesicles and the function of AP‐3 and the v‐SNARE (vesicular soluble N ‐ethylmaleimide‐sensitive fusion protein‐attachment protein receptor) TI‐VAMP (tetanus neurotoxin‐insensitive vesicle‐associated membrane protein) in these processes. We propose that AP‐3 plays an important regulatory role in neurons which contributes to the basal and stimulated exocytosis of synaptic vesicles.