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Positioning centrosomes and spindle poles: looking at the periphery to find the centre
Author(s) -
Manneville JeanBaptiste,
EtienneManneville Sandrine
Publication year - 2006
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1042/bc20060017
Subject(s) - centrosome , spindle pole body , biology , microbiology and biotechnology , centrosome cycle , microtubule , astral microtubules , spindle apparatus , microtubule nucleation , mitosis , microtubule organizing center , cell cortex , interphase , multipolar spindles , cell division , cell , cell cycle , genetics , cytoskeleton
Centrosome positioning is tightly controlled throughout the cell cycle and probably shares common regulatory mechanisms with spindle‐pole positioning. In this article, we detail the possible mechanisms controlling centrosome and spindle positioning in various organisms both in interphase and mitotic cells, and discuss recent findings showing how microtubule plus‐end‐associated proteins interact with the cell cortex. We suggest that microtubule plus‐end complexes simultaneously regulate microtubule dynamics and microtubule anchoring at the cell periphery to allow proper centrosome and spindle‐pole positioning.