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Our favourite alternative splice site
Author(s) -
Lerivray Hubert,
Méreau Agnès,
Osborne H. Beverley
Publication year - 2006
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1042/bc20050084
Subject(s) - biology , alternative splicing , rna splicing , computational biology , gene , genetics , favourite , splice , genome , mechanism (biology) , function (biology) , exon , rna , philosophy , theology , epistemology
Alternative splicing is a widespread mechanism in mammals that generates several mRNAs from one gene, thereby creating genetic diversity of the genome. Variant splice patterns are often specific to different stages of development or particular tissues, and alternative splicing defects are being more frequently detected in genetic diseases and cancers. The increasingly important role of alternative splicing in the function and the regulation of cellular process makes it critical to have an easy‐to‐use data repository for the biological and medical research communities. We have compared web resources that give access to information on alternatively spliced genes, and the FAST DB (Friendly Alternative Splicing and Transcripts DataBase) site came out as our favourite.