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The Protein Kinase Resource: everything you always wanted to know about protein kinases but were afraid to ask
Author(s) -
Petretti Clotilde,
Prigent Claude
Publication year - 2005
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1042/bc20040077
Subject(s) - biology , kinase , protein phosphorylation , scaffold protein , microbiology and biotechnology , dephosphorylation , phosphorylation , phosphatase , protein kinase a , cdc37 , grb10 , signal transduction , extracellular signal regulated kinases , insulin resistance , endocrinology , insulin , insulin receptor
Protein kinases and phosphatases play crucial roles in all the major cellular processes, such as signal transduction, cell differentiation, cell proliferation and cell cycle progression. Protein phosphorylation or dephosphorylation can form the basis of many critical processes, including enzyme activation or inactivation, protein localization and protein degradation. Given the importance of protein kinases to cellular development and function, it is critical that there are effective ways of disseminating information on protein kinases to the research community. This review describes such a web resource, 'The Protein Kinase Resource' (http://pkr.sdsc.edu/html/index.shtml), which serves as a repository for cellular and molecular data on protein kinases.