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Putting RNAs in the right place at the right time: RNA localization in the frog oocyte
Author(s) -
King Mary Lou,
Messitt Timothy J.,
Mowry Kimberly L.
Publication year - 2005
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1042/bc20040067
Subject(s) - biology , oocyte , rna , microbiology and biotechnology , computational biology , genetics , embryo , gene
Localization of maternal mRNAs in many developing organisms provides the basis for both initial polarity during oogenesis and patterning during embryogenesis. Prominent examples of this phenomenon are found in Xenopus laevis , where localized maternal mRNAs generate developmental polarity along the animal/vegetal axis. Targeting of mRNA molecules to specific subcellular regions is a fundamental mechanism for spatial regulation of gene expression, and considerable progress has been made in defining the underlying molecular pathways.