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Tissue‐engineered skin substitutes: from in vitro constructs to in vivo applications
Author(s) -
Auger François A.,
Berthod François,
Moulin Véronique,
Pouliot Roxane,
Germain Lucie
Publication year - 2004
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1042/ba20030229
Subject(s) - in vivo , in vitro , tissue engineering , neovascularization , biomedical engineering , microbiology and biotechnology , biology , medicine , angiogenesis , biochemistry , cancer research
The field of skin tissue engineering is a paradigm for the various efforts towards the reconstruction of other tissues and organ substitutes. As skin replacement, this biotechnological approach has evolved from simple cultured autologous epidermal sheets to more complex bilayered cutaneous substitutes. The various types of such substitutes are herein presented with their intended use. However, two integrative characteristics are analysed more specifically because of their critical role: neovascularization and re‐innervation. Furthermore, the in vitro use of these various skin substitutes has shed light on various physiological and pathological phenomena. Thus, not only the in vivo application of these skin substitutes as grafts, but also their in vitro value as skin models, are presented.