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Preparation and characterization of a new bioinorganic composite: collagen and hydroxyapatite
Author(s) -
Mythili J.,
Sastry T. P.,
Subramanian M.
Publication year - 2000
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1042/ba20000055
Subject(s) - biomineralization , calcification , bioinorganic chemistry , composite number , matrix (chemical analysis) , hydroxyapatites , chemistry , characterization (materials science) , salt (chemistry) , chemical engineering , materials science , calcium , mineralogy , nanotechnology , nuclear chemistry , biochemistry , composite material , chromatography , organic chemistry , pathology , medicine , engineering
Studies on biomineralization in bone have opened new arenas in the field of fabrication and engineering of bone‐graft devices. A new bioinorganic composite was prepared by introducing processed collagenous matrices into the calcifying solutions at pH 7.8–8.0. The calcifying solutions were prepared by using a saturated dicalcium salt solution. Hydroxyapatite grew on the matrix over a period of 3–5 days in a specially designed crystallizing chamber. Changes in biochemical characters and biophysical parameters have given interesting insights into factors affecting and effecting initiation and progression of calcification on organic matrices.