Arylopeptoid oligomers functionalised by combinatorial or sequential on-resin click chemistry using a copper(i)–N-heterocyclic carbene catalyst | Zendy

Ayman Akhdar | Zendy; Sophie Faure | Zendy; Arnaud Gautier | Zendy

Open Access

Arylopeptoid oligomers functionalised by combinatorial or sequential on-resin click chemistry using a copper(i)–N-heterocyclic carbene catalyst

Author(s) -

Ayman Akhdar,

Sophie Faure,

Arnaud Gautier

Publication year - 2022

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/d2ob00163b

Subject(s) - carbene , chemistry , click chemistry , catalysis , copper , surface modification , combinatorial chemistry , oligomer , polymer chemistry , alkylation , organic chemistry

An efficient on-resin click chemistry protocol using a stable copper(I)-N-heterocyclic carbene catalyst is developed for post-functionalization of N -alkylated aminomethylbenzamide oligomers (arylopeptoids). The accessibility to a panel of polyfunctionalized N -substituted aromatic oligoamides by solid-phase synthesis is demonstrated using combinatorial and sequential approaches.

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