Open AccessPalladium-catalyzed directed synthesis of ortho-deuterated phenylacetic acid and analogues
Author(s) -
Priyadarshi Manna,
Mrinalkanti Kundu,
Ashis Roy,
Susanta Adhikari
Publication year - 2021
Publication title -
organic and biomolecular chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 146
eISSN - 1477-0539
pISSN - 1477-0520
DOI - 10.1039/d1ob00663k
Subject(s) - chemistry , phenylacetic acid , deuterium , catalysis , context (archaeology) , combinatorial chemistry , organic synthesis , molecule , enantioselective synthesis , organic chemistry , physics , quantum mechanics , biology , paleontology
An efficient method for directed ortho -selective H/D-exchange of 2-pyridone containing phenylacetic acid amides is presented which has been implemented to synthesize a medicinally important compound in gram scale with excellent deuterium enrichment.