Open AccessHarnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions
Author(s) -
Freideriki Michailidou,
Andrea Rentmeister
Publication year - 2021
Publication title -
organic and biomolecular chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 146
eISSN - 1477-0539
pISSN - 1477-0520
DOI - 10.1039/d1ob00354b
Subject(s) - methylation , chemistry , alkylation , cascade , biocatalysis , enzyme , small molecule , computational biology , combinatorial chemistry , nanotechnology , biochemical engineering , biochemistry , biology , dna , reaction mechanism , catalysis , materials science , chromatography , engineering
Enzyme-mediated methylation is a very important reaction in nature, yielding a wide range of modified natural products, diversifying small molecules and fine-tuning the activity of biomacromolecules. The field has attracted much attention over the recent years and interesting applications of the dedicated enzymes in biocatalysis and biomolecular labelling have emerged. In this review article, we summarise the concepts and recent advances in developing (chemo)-enzymatic cascades for selective methylation, alkylation and photocaging as tools to study biological methylation and as biotransformations to generate site-specifically alkylated products.