Open AccessRecent advances in the development of covalent inhibitors
Author(s) -
Hyunsoo Kim,
Yoon Soo Hwang,
Mingi Kim,
Seung Bum Park
Publication year - 2021
Publication title -
rsc medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 55
ISSN - 2632-8682
DOI - 10.1039/d1md00068c
Subject(s) - covalent bond , drug development , covalent binding , chemistry , drug discovery , nanotechnology , pharmacology , drug , materials science , biochemistry , medicine , organic chemistry
The use of covalent inhibitors in the field of drug discovery has attracted considerable attention in the 2000s. As a result, more than 50 covalent drugs are currently on the market, and numerous covalent drug candidates are now under development. Therefore, interest in covalent drugs is expected to continue in the future. The purpose of this focused review is to provide an understanding of the development of covalent inhibitors by describing their inherent characteristics, possibilities, and limitations based on their mechanistic differences from noncovalent inhibitors. We also introduce the latest covalent warheads that can be applied to the development of potential covalent inhibitors.