Open AccessEvolution towards green radical generation in total synthesis
Author(s) -
Matthew S. Galliher,
Bec J. Roldan,
Corey R. J. Stephenson
Publication year - 2021
Publication title -
chemical society reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 15.598
H-Index - 513
eISSN - 1460-4744
pISSN - 0306-0012
DOI - 10.1039/d1cs00411e
Subject(s) - radical , total synthesis , hydride , chemistry , photoredox catalysis , electrochemistry , catalysis , metal , photochemistry , nanotechnology , combinatorial chemistry , organic chemistry , materials science , photocatalysis , electrode
The use of radicals as intermediates in total synthesis has evolved since their initial use in the latter half of the twentieth century. Radical generation from metal hydride methodologies has shifted to "greener" techniques including catalytic metal-mediated systems, electrochemical and photoredox-mediated processes. This review will focus on these classical and contemporary methods for radical generation and their applications in recent total syntheses.