Open AccessTransition metal-catalysed carbene- and nitrene transfer to carbon monoxide and isocyanides
Author(s) -
Thomas R. Roose,
Daniël S. Verdoorn,
Pieter Mampuys,
Eelco Ruijter,
Bert U. W. Maes,
Romano V. A. Orrù
Publication year - 2022
Publication title -
chemical society reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 15.598
H-Index - 513
eISSN - 1460-4744
pISSN - 0306-0012
DOI - 10.1039/d1cs00305d
Subject(s) - nitrene , carbene , carbon monoxide , chemistry , transition metal , combinatorial chemistry , photochemistry , organic chemistry , catalysis
Transition metal-catalysed carbene- and nitrene transfer to the C1-building blocks carbon monoxide and isocyanides provides heteroallenes ( i.e. ketenes, isocyanates, ketenimines and carbodiimides). These are versatile and reactive compounds allowing in situ transformation towards numerous functional groups and organic compounds, including heterocycles. Both one-pot and tandem processes have been developed providing valuable synthetic methods for the organic chemistry toolbox. This review discusses all known transition metal-catalysed carbene- and nitrene transfer reactions towards carbon monoxide and isocyanides and in situ transformation of the heteroallenes hereby obtained, with a special focus on the general mechanistic considerations.