Open AccessHydroxyl radical is a significant player in oxidative DNA damage in vivo
Author(s) -
Barry Halliwell,
Amitava Adhikary,
M. Dingfelder,
Miral Dizdaroğlu
Publication year - 2021
Publication title -
chemical society reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 15.598
H-Index - 513
eISSN - 1460-4744
pISSN - 0306-0012
DOI - 10.1039/d1cs00044f
Subject(s) - hydroxyl radical , in vivo , chemistry , oxidative damage , reactive oxygen species , oxidative phosphorylation , dna damage , dna , biophysics , biochemistry , oxidative stress , radical , biology , genetics
Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO 3 ˙ - ) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.