Open AccessStructure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune systemviathe human oligoadenylate synthase 1
Author(s) -
Emmanuelle Big,
Tom Miclot,
Alessio Terenzi,
Giampaolo Barone,
Antonio Monari
Publication year - 2022
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d1cc07006a
Subject(s) - innate immune system , rna , untranslated region , three prime untranslated region , biology , genome , rnase p , immune system , virology , chemistry , genetics , gene
The structure of the RNA SL1 of the 5′-untranslated region of SARS-CoV-2 genome is investigated. We also highlight the specific interactions of SL1 with OAS1 triggering the innate immune response.