Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates | Zendy

Zhouyang Huang | Zendy; Anna King | Zendy; James H. Lovett | Zendy; Barry Lai | Zendy; Joshua J. Woods | Zendy; Hugh H. Harris | Zendy; Justin J. Wilson | Zendy

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Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates

Author(s) -

Zhouyang Huang,

Anna King,

James H. Lovett,

Barry Lai,

Joshua J. Woods,

Hugh H. Harris,

Justin J. Wilson

Publication year - 2021

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d1cc04669a

Subject(s) - colocalization , conjugate , in vitro , chemistry , fluorescence , fluorescence microscope , cancer cell , irradiation , biophysics , biochemistry , cancer , microbiology and biotechnology , biology , mathematical analysis , physics , genetics , mathematics , quantum mechanics , nuclear physics

The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.

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