Open AccessRecent advances in palladium-catalyzed (hetero)annulation of CC bonds with ambiphilic organo(pseudo)halides
Author(s) -
HuiQi Ni,
Phillippa Cooper,
Keary M. Engle
Publication year - 2021
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d1cc02836g
Subject(s) - annulation , halide , palladium , catalysis , chemistry , combinatorial chemistry , medicinal chemistry , polymer chemistry , organic chemistry
Palladium has proven to be effective in catalyzing the (hetero)annulation of C[double bond, length as m-dash]C bonds with ambiphilic organo(pseudo)halides. Through the employment of appropriate ambiphilic coupling partners, efficient annulation of a variety of allenes, 1,3-dienes, strained alkenes, styrenes, and other C[double bond, length as m-dash]C bond variants can be achieved to provide direct access to numerous useful hetero- and carbocyclic scaffolds. In this Feature Article, we summarize palladium-catalyzed (hetero)annulation methods reported since 2005 (spanning just over 15 years) and discuss outstanding challenges in this area of study.