Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy | Zendy

Dali Sun | Zendy; Li Yang | Zendy; Christopher J. Lyon | Zendy; Tony Hu | Zendy

Open Access

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

Author(s) -

Dali Sun,

Li Yang,

Christopher J. Lyon,

Tony Hu

Publication year - 2020

Publication title -

journal of materials chemistry b

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.316

H-Index - 101

eISSN - 2050-7518

pISSN - 2050-750X

DOI - 10.1039/d0tb00350f

Subject(s) - dark field microscopy , materials science , magnification , microscopy , scattering , field (mathematics) , nanoparticle , nanotechnology , analytical chemistry (journal) , optics , chromatography , chemistry , physics , mathematics , pure mathematics

Nanoparticle-enhanced assays read by high-magnification dark-field microscopy require time-intensive analysis methods subject to selection bias, which can be resolved by using low magnification dark-field assays (LMDFA), at the cost of reduced sensitivity. We have simulated and experimentally validated a tunable linker-based signal amplification strategy yielding 6-fold enhanced LMDFA sensitivity.

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