Open AccessLong-range mechanical signaling in biological systems
Author(s) -
Farid Alisafaei,
Xingyu Chen,
Thomas Leahy,
Paul A. Janmey,
Vivek B. Shenoy
Publication year - 2021
Publication title -
soft matter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 170
eISSN - 1744-6848
pISSN - 1744-683X
DOI - 10.1039/d0sm01442g
Subject(s) - protein filament , extracellular matrix , cytoskeleton , biophysics , fiber , matrix (chemical analysis) , cell , biological system , nanotechnology , chemistry , materials science , biology , microbiology and biotechnology , biochemistry , organic chemistry , chromatography
Cells can respond to signals generated by other cells that are remarkably far away. Studies from at least the 1920's showed that cells move toward each other when the distance between them is on the order of a millimeter, which is many times the cell diameter. Chemical signals generated by molecules diffusing from the cell surface would move too slowly and dissipate too fast to account for these effects, suggesting that they might be physical rather than biochemical. The non-linear elastic responses of sparsely connected networks of stiff or semiflexible filament such as those that form the extracellular matrix (ECM) and the cytoskeleton have unusual properties that suggest multiple mechanisms for long-range signaling in biological tissues. These include not only direct force transmission, but also highly non-uniform local deformations, and force-generated changes in fiber alignment and density. Defining how fibrous networks respond to cell-generated forces can help design new methods to characterize abnormal tissues and can guide development of improved biomimetic materials.