Characterization in aqueous medium of an FMN semiquinone radical stabilized by the enzyme-like microenvironment of a modified polyethyleneimine | Zendy

Yoan Chevalier | Zendy; Yvette Lock Toy Ki | Zendy; Christian Herrero | Zendy; Didier Le Nouën | Zendy; JeanPierre Mahy | Zendy; JeanPhilippe Goddard | Zendy; Frédéric Avenier | Zendy

Open Access

Characterization in aqueous medium of an FMN semiquinone radical stabilized by the enzyme-like microenvironment of a modified polyethyleneimine

Author(s) -

Yoan Chevalier,

Yvette Lock Toy Ki,

Christian Herrero,

Didier Le Nouën,

JeanPierre Mahy,

JeanPhilippe Goddard,

Frédéric Avenier

Publication year - 2020

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/d0ob00864h

Subject(s) - semiquinone , flavoprotein , flavin group , cofactor , chemistry , aqueous solution , photochemistry , enzyme , aqueous medium , riboflavin , biochemistry , organic chemistry , quinone

The elusive flavin semiquinone intermediate found in flavoproteins such as cryptochromes has been obtained in aqueous solution by single electron reduction of the natural FMN cofactor using sodium ascorbate. This species was formed in the local hydrophobic microenvironment of a modified polyethyleneimine and characterized by UV-Visible, fluorescence and EPR spectroscopies.

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