Open AccessEfficient in vivo wound healing using noble metal nanoclusters
Author(s) -
Kuo Li,
Dan Li,
ChengHsuan Li,
Pengfei Zhuang,
Chunmei Dai,
Xiangka Hu,
Dahao Wang,
Yuanye Liu,
Xifan Mei,
Vincent M. Rotello
Publication year - 2021
Publication title -
nanoscale
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.038
H-Index - 224
eISSN - 2040-3372
pISSN - 2040-3364
DOI - 10.1039/d0nr07176e
Subject(s) - nanoclusters , in vivo , wound healing , noble metal , materials science , metal , nanotechnology , biomedical engineering , medicine , surgery , metallurgy , biology , microbiology and biotechnology
The wound healing process involves multiple steps including hemostasis, inflammation, proliferation, and tissue remodeling. Nanomaterials have been employed externally for healing wounds. However, their use as systemic therapeutics has not been extensively explored. We report the use of ultra-small noble metal nanoclusters (NCs) for the treatment of skin wounds. Both in vitro and in vivo studies indicate NCs have comprehensive therapeutic effects for wound healing, promoting cell proliferation and migration while decreasing inflammation.