MicroED in natural product and small molecule research | Zendy

Emma Danelius | Zendy; Steve Halaby | Zendy; Wilfred A. van der Donk | Zendy; Tamir Gonen | Zendy

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MicroED in natural product and small molecule research

Author(s) -

Emma Danelius,

Steve Halaby,

Wilfred A. van der Donk,

Tamir Gonen

Publication year - 2020

Publication title -

natural product reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.703

H-Index - 177

eISSN - 1460-4752

pISSN - 0265-0568

DOI - 10.1039/d0np00035c

Subject(s) - cryo electron microscopy , electron microscope , amorphous solid , nanotechnology , materials science , resolution (logic) , diffraction , electron diffraction , product (mathematics) , high resolution , crystallography , chemistry , physics , optics , computer science , nuclear magnetic resonance , geology , geometry , mathematics , remote sensing , artificial intelligence

Covering: 2013 to 2020The electron cryo-microscopy (cryo-EM) method Microcrystal Electron Diffraction (MicroED) allows the collection of high-resolution structural data from vanishingly small crystals that appear like amorphous powders or very fine needles. Since its debut in 2013, data collection and analysis schemes have been fine-tuned, and there are currently close to 100 structures determined by MicroED. Although originally developed to study proteins, MicroED is also very powerful for smaller systems, with some recent and very promising examples from the field of natural products. Herein, we review what has been achieved so far and provide examples of natural product structures, as well as demonstrate the expected future impact of MicroED to the field of natural product and small molecule research.

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