Open AccessCytotoxic and antitumor peptides as novel chemotherapeutics
Author(s) -
Xin Luan,
Ye Wu,
Yiwen Shen,
Hong Zhang,
Yifeng Zhou,
Hongzhuan Chen,
Dale G. Nagle,
Guoqing Zhang
Publication year - 2021
Publication title -
natural product reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.703
H-Index - 177
eISSN - 1460-4752
pISSN - 0265-0568
DOI - 10.1039/d0np00019a
Subject(s) - cytotoxic t cell , broad spectrum , drug , drug resistance , pharmacology , computational biology , biology , chemistry , combinatorial chemistry , in vitro , microbiology and biotechnology , biochemistry
Covering: up to 2020Treatment resistance and drug-induced refractory malignancies pose significant challenges for current chemotherapy drugs. There have been increasing research efforts aimed at developing novel chemotherapeutics, especially from natural products and related derivatives. Natural cytotoxic peptides, an emerging source of chemotherapeutics, have exhibited the advantage of overcoming drug resistance and displayed broad-spectrum antitumor activities in the clinic. This highlight examines the increasingly popular cytotoxic peptides from isolated natural products. In-depth review of several peptides provides examples for how this novel strategy can lead to the improved anti-tumor effects. The mechanisms and current application of representative natural cytotoxic peptides (NCPs) have also been discussed, with a particular focus on future directions for interdisciplinary research.