Antibiotic administration in targeted nanoparticles protects the faecal microbiota of mice | Zendy

Baris A. Borsa | Zendy; Mert Sudağıdan | Zendy; Mehmet Ersoy Aldağ | Zendy; Isik I. Baris | Zendy; Elif Esma Acar | Zendy; Cağatay Acuner | Zendy; Murat Kavruk | Zendy; Veli Cengiz Özalp | Zendy

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Antibiotic administration in targeted nanoparticles protects the faecal microbiota of mice

Author(s) -

Baris A. Borsa,

Mert Sudağıdan,

Mehmet Ersoy Aldağ,

Isik I. Baris,

Elif Esma Acar,

Cağatay Acuner,

Murat Kavruk,

Veli Cengiz Özalp

Publication year - 2021

Publication title -

rsc medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 55

ISSN - 2632-8682

DOI - 10.1039/d0md00347f

Subject(s) - teicoplanin , staphylococcus aureus , antibiotics , dysbiosis , mesoporous silica , microbiology and biotechnology , gut flora , chemistry , medicine , biology , bacteria , vancomycin , immunology , mesoporous material , genetics , biochemistry , catalysis

Antibiotic therapy comes with disturbances on human microbiota, resulting in changes of bacterial communities and thus leading to well-established health problems. In this study, we demonstrated that targeted teicoplanin administration maintains the faecal microbiota composition undisturbed in a mouse model while reaching therapeutic improvements for S. aureus infection.

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