Open AccessAntibiotic administration in targeted nanoparticles protects the faecal microbiota of mice
Author(s) -
Barış Ata Borsa,
Mert Sudağıdan,
Mehmet Ersoy Aldağ,
Isik I Baris,
Elif Esma Acar,
Cağatay Acuner,
Murat Kavruk,
Veli Cengiz Özalp
Publication year - 2021
Publication title -
rsc medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 55
ISSN - 2632-8682
DOI - 10.1039/d0md00347f
Subject(s) - teicoplanin , staphylococcus aureus , antibiotics , dysbiosis , mesoporous silica , microbiology and biotechnology , gut flora , chemistry , medicine , biology , bacteria , vancomycin , immunology , mesoporous material , genetics , biochemistry , catalysis
Antibiotic therapy comes with disturbances on human microbiota, resulting in changes of bacterial communities and thus leading to well-established health problems. In this study, we demonstrated that targeted teicoplanin administration maintains the faecal microbiota composition undisturbed in a mouse model while reaching therapeutic improvements for S. aureus infection.