Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography | Zendy

Chungha Lee | Zendy; Seunggyu Kim | Zendy; Hervé Hugonnet | Zendy; Moosung Lee | Zendy; Weisun Park | Zendy; Jessie S. Jeon | Zendy; YongKeun Park | Zendy

Open Access

Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography

Author(s) -

Chungha Lee,

Seunggyu Kim,

Hervé Hugonnet,

Moosung Lee,

Weisun Park,

Jessie S. Jeon,

YongKeun Park

Publication year - 2021

Publication title -

lab on a chip

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.064

H-Index - 210

eISSN - 1473-0197

pISSN - 1473-0189

DOI - 10.1039/d0lc01061h

Subject(s) - vasculogenesis , diffraction , diffraction tomography , refractive index , tomography , organelle , biomedical engineering , chip , optics , materials science , chemistry , microbiology and biotechnology , biology , computer science , optoelectronics , endothelial stem cell , physics , medicine , biochemistry , telecommunications , in vitro

Label-free, three-dimensional (3D) quantitative observations of on-chip vasculogenesis were achieved using optical diffraction tomography. Exploiting 3D refractive index maps as an intrinsic imaging contrast, the vascular structures, multicellular activities, and subcellular organelles of endothelial cells were imaged and analysed throughout vasculogenesis to characterise mature vascular networks without exogenous labelling.

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