An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery | Zendy

Bo Wang | Zendy; Ximiao Wen | Zendy; Yan Cao | Zendy; Shan Huang | Zendy; Hoa A. Lam | Zendy; Tingyi Liu | Zendy; PeiShan Chung | Zendy; Harold G. Monbouquette | Zendy; PeiYu Chiou | Zendy; Nigel T. Maidment | Zendy

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An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

Author(s) -

Bo Wang,

Ximiao Wen,

Yan Cao,

Shan Huang,

Hoa A. Lam,

Tingyi Liu,

PeiShan Chung,

Harold G. Monbouquette,

PeiYu Chiou,

Nigel T. Maidment

Publication year - 2020

Publication title -

lab on a chip

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.064

H-Index - 210

eISSN - 1473-0197

pISSN - 1473-0189

DOI - 10.1039/d0lc00021c

Subject(s) - analyte , microprobe , materials science , nanotechnology , biomedical engineering , chemistry , chromatography , engineering , mineralogy

A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.

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