Open AccessAn implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery
Author(s) -
Bo Wang,
Ximiao Wen,
Yunning Cao,
Shan Huang,
Hoa A. Lam,
Tingyi Liu,
PeiShan Chung,
Harold G. Monbouquette,
Pei-Yu Chiou,
Nigel T. Maidment
Publication year - 2020
Publication title -
lab on a chip
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.064
H-Index - 210
eISSN - 1473-0197
pISSN - 1473-0189
DOI - 10.1039/d0lc00021c
Subject(s) - analyte , microprobe , materials science , nanotechnology , biomedical engineering , chemistry , chromatography , engineering , mineralogy
A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.