Open AccessMicrofluidic lumen-based systems for advancing tubular organ modeling
Author(s) -
María Virumbrales-Muñoz,
José M. Ayuso,
Ming Gong,
Mouhita Humayun,
Megan Livingston,
Karina M Lugo-Cintrón,
Patrick H. McMinn,
Yasmín R. Álvarez-García,
David J. Beebe
Publication year - 2020
Publication title -
chemical society reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 15.598
H-Index - 513
eISSN - 1460-4744
pISSN - 0306-0012
DOI - 10.1039/d0cs00705f
Subject(s) - lumen (anatomy) , microfluidics , microscale chemistry , lymphatic system , organ system , drug discovery , drug development , gastrointestinal tract , computational biology , computer science , biology , nanotechnology , medicine , bioinformatics , pathology , drug , microbiology and biotechnology , materials science , pharmacology , disease , mathematics education , mathematics
Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human pathophysiology and predict drug response, having profound implications for drug discovery and development. Herein, we review progress in the development of microfluidic lumen-based models from the 2000s to the present. The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-specific diseases. We also highlight emerging application areas, such as the lymphatic system, and close the review discussing potential future directions.