Open AccessIon mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions
Author(s) -
Cagla Sahin,
Nicklas Österlund,
Axel Leppert,
Joel Johansson,
Erik Marklund,
Justin L. P. Benesch,
Leopold L. Ilag,
Timothy M. Allison,
Michael Landreh
Publication year - 2021
Publication title -
chemical communications
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc08135c
Subject(s) - ion mobility spectrometry , ion , mass spectrometry , chemistry , chromatography , organic chemistry
Although native mass spectrometry is widely applied to monitor chemical or thermal protein denaturation, it is not clear to what extent it can inform about alkali-induced unfolding.