Open AccessCopper-catalyzed enantioselective synthesis of bridged bicyclic ketals from 1,1-disubstituted-4-methylene-1,6-hexanediols and related alkenols
Author(s) -
Ameya S. Burde,
Shuklendu D. Karyakarte,
Eric D. Sylvester,
Sherry R. Chemler
Publication year - 2021
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc06404a
Subject(s) - enantioselective synthesis , bicyclic molecule , alkene , methylene , chemistry , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
Bridged bicyclic ketals display a range of bioactivities. Their catalytic enantioselective synthesis from acyclic 1,1-disubstituted alkene diols is disclosed. This reaction combines asymmetric catalysis with a distal radical migration. Alkynes and arenes undergo the group transfer.