Copper-catalyzed enantioselective synthesis of bridged bicyclic ketals from 1,1-disubstituted-4-methylene-1,6-hexanediols and related alkenols | Zendy

Ameya S. Burde | Zendy; Shuklendu D. Karyakarte | Zendy; Eric D. Sylvester | Zendy; Sherry R. Chemler | Zendy

Open Access

Copper-catalyzed enantioselective synthesis of bridged bicyclic ketals from 1,1-disubstituted-4-methylene-1,6-hexanediols and related alkenols

Author(s) -

Ameya S. Burde,

Shuklendu D. Karyakarte,

Eric D. Sylvester,

Sherry R. Chemler

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc06404a

Subject(s) - enantioselective synthesis , bicyclic molecule , alkene , methylene , chemistry , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry

Bridged bicyclic ketals display a range of bioactivities. Their catalytic enantioselective synthesis from acyclic 1,1-disubstituted alkene diols is disclosed. This reaction combines asymmetric catalysis with a distal radical migration. Alkynes and arenes undergo the group transfer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research